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近日， Innate Pharma 和 赛诺菲 宣布扩大合作，赛诺菲将从 Innate 公司的  ANKET

TM

（ Antibody-based NK Cell Engager Therapeutics ） 平台获得针对 B7H3 的自然杀伤 （ NK ） 细胞接合剂（Engager）项目的授权。此外，赛诺菲还可以选择增加两个额外的  ANKET

TM

靶点。确定候选药物后，赛诺菲将负责所有的开发、制造和商业化。

根据最新的许可协议， 赛诺菲 将向 Innate 支付 2640 万美元的预付款。Innate 还有资格获得总计 高达 14.3 亿美元 的临床前、临床、监管和商业里程碑付款以及未来净销售额的特许权使用费。

早在2016年，两家公司就签署了一项价值 4 亿美元的研究合作和许可协议，以开发和评估最多两种双特异性 NK 细胞接合剂。目前 赛诺菲 的研发团队正在对其进行评估。

其中一种名为 SAR443579 的药物靶向受体 CD123，目前正处于针对已逝或难治性急性髓性白血病、B 细胞急性淋巴细胞白血病和高危骨髓增生异常综合征的 I/II 期试验。 赛诺菲 还决定将另一种候选药物——一种名为 SAR445514 的 BCMA 靶向 NK 细胞接合剂，推进人体临床试验。

在周一早上发布的新闻稿中， 赛诺菲 全球肿瘤学研究负责人 Valeria Fantin 博士表示， 该公司正在继续探索“NK 细胞在癌症免疫治疗中的潜力，属于赛诺菲肿瘤学战略的关键支柱。 ”

“我们与 Innate 的关系符合我们与有前途的法国公司合作的承诺，并支持我们开发下一代 NK 细胞接合剂的多样化产品组合的雄心，与 赛诺菲 的同种异体 NK 细胞平台、刺激 NK 细胞和增强免疫力的工程淋巴因子高度协同。” Fantin 表示。

早在 2020 年， 赛诺菲 就以 3.58 亿美元的价格收购了同种异体 NK 细胞平台开发商 Kiadis Pharma ；今年 9 月，赛诺菲与 Scribe Therapeutics 签署了一项协议，将利用 Scribe Therapeutics 的 CRISPR 基因组编辑技术，使用于癌症的新型自然杀伤 (NK) 细胞疗法的基因改造。

合作，赛诺菲将从Innate公司的ANKETTM(Antibody-based NK Cell Engager Therapeutics)平台来靶向在各种实体瘤上过度表达的糖蛋白 B7H3。此外，赛诺菲还可以选择增加两个额外的ANKETTM靶点。确定候选药物后，赛诺菲将负责所有的开发、制造和商业化。"}}},"align":"","folded":false}},"Pkswd0y0mo4Ae0xxUMhc6eynnIc":{"id":"Pkswd0y0mo4Ae0xxUMhc6eynnIc","snapshot":{"type":"text","parent_id":"ZgpPdjp3YowvBmx3FUYcyhnRn2f","comments":[],"locked":false,"hidden":false,"author":"6980198808172969986","children":[],"text":{"apool":{"nextNum":0,"numToAttrib":{}},"initialAttributedTexts":{"attribs":{"0":""},"text":{"0":""}}},"align":"","folded":false}},"RCSEdakOeoQQsyxKSjUcVDrhncf":{"id":"RCSEdakOeoQQsyxKSjUcVDrhncf","snapshot":{"type":"text","parent_id":"ZgpPdjp3YowvBmx3FUYcyhnRn2f","comments":[],"locked":false,"hidden":false,"author":"6980198808172969986","children":[],"text":{"apool":{"nextNum":2,"numToAttrib":{"0":["author","6980198808172969986"],"1":["bold","true"]}},"initialAttributedTexts":{"attribs":{"0":"*0+1i*0*1+b*0+z"},"text":{"0":"根据最新的许可协议，赛诺菲将向 Innate 支付 2640 万美元的预付款。Innate 还有资格获得总计高达 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